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- Title
Treatment of prosthetic tricuspid valve thrombosis with recombinant tissue-type plasminogen activator.
- Authors
CAMBIER, P.; MOMBAERTS, P.; DE GEEST, H.; COLLEN, D.; VAN DE WERF, F.
- Abstract
Recombinant tissue-type plasminogen activator (rt-PA) was admministered intravenously to a 64-years old female with thrombotic malfunction of a Björk–Shiley prosthetic tricuspid valve. 150 mg of single-chain rt-PA was infused over 8 hours followed by an additional dose of 50 mg over the next 8 hours. At the end of the first infusion, restoration of normal valve function was demonstrated by fluoroscopic and echo-Doppler examinations. Mild systemic activation of the fibrinolytic system occurred, with a decrease of fibrinogen and α-antiplasmin to 53% and 33%, respectively, of the preinfusion value at the nadir.
- Publication
European Heart Journal, 1987, Vol 8, Issue 7, p906
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/oxfordjournals.eurheartj.a062356