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- Title
Magnesium Corrosion Triggered Spontaneous Generation of H<sub>2</sub>O<sub>2</sub> on Oxidized Titanium for Promoting Angiogenesis.
- Authors
Park, Jimin; Du, Ping; Jeon, Jin‐Kyung; Jang, Gun Hyuk; Hwang, Mintai Peter; Han, Hyung‐Seop; Park, Kwideok; Lee, Kwan Hyi; Lee, Jee‐Wook; Jeon, Hojeong; Kim, Yu‐Chan; Park, Jong Woong; Seok, Hyun‐Kwang; Ok, Myoung‐Ryul
- Abstract
Although the use of reactive oxygen species (ROS) has been extensively studied, current systems employ external stimuli such as light or electrical energy to produce ROS, which limits their practical usage. In this report, biocompatible metals were used to construct a novel electrochemical system that can spontaneously generate H2O2 without any external light or voltage. The corrosion of Mg transfers electrons to Audecorated oxidized Ti in an energetically favorable process, and the spontaneous generation of H2O2 in an oxygen reduction reaction was revealed to occur at titanium by combined spectroscopic and electrochemical analyses. The controlled release of H2O2 noticeably enhanced in vitro angiogenesis even in the absence of growth factors. Finally, a new titanium implant prototype was developed by Mg incorporation, and its potential for promoting angiogenesis was demonstrated.
- Subjects
BIOMEDICAL materials; ELECTROCHEMICAL apparatus; HYDROGEN peroxide synthesis; MAGNESIUM; TITANIUM; OXYGEN reduction; ARTIFICIAL implants; NEOVASCULARIZATION
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 49, p14753
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201507352