We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Dopaminergic neuromodulation has no detectable effect on visual-cue induced haemodynamic response function in the visual cortex: A double-blind, placebo-controlled functional magnetic resonance imaging study.
- Authors
Manoliu, Andrei; Sladky, Ronald; Scherpiet, Sigrid; Jäncke, Lutz; Kirschner, Matthias; Haugg, Amelie; Bolsinger, Julia; Kraehenmann, Rainer; Stämpfli, Philipp; Scharnowski, Frank; Herwig, Uwe; Seifritz, Erich; Brühl, Annette B
- Abstract
The aim of this study was to investigate the effect of acute dopamine agonistic and antagonistic manipulation on the visual-cue induced blood oxygen level-dependent signal response in healthy volunteers. Seventeen healthy volunteers in a double-blind placebo-controlled cross-over design received either a dopamine antagonist, agonist or placebo and underwent functional magnetic resonance imaging. Using classical inference and Bayesian statistics, we found no effect of dopaminergic modulation on properties of visual-cue induced blood oxygen level-dependent signals in the visual cortex, particularly on distinct properties of the haemodynamic response function (amplitude, time-to-peak and width). Dopamine-related effects modulating the neurovascular coupling in the visual cortex might be negligible when measured via functional magnetic resonance imaging.
- Subjects
FUNCTIONAL magnetic resonance imaging; VISUAL cortex; HEMODYNAMICS; OXYGEN in the blood; DIAGNOSTIC imaging; DOPAMINE antagonists; INFERENTIAL statistics
- Publication
Journal of Psychopharmacology, 2021, Vol 35, Issue 1, p100
- ISSN
0269-8811
- Publication type
Article
- DOI
10.1177/0269881120972341