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- Title
The trajectory of the blood DNA methylome ageing rate is largely set before adulthood: evidence from two longitudinal studies.
- Authors
Kananen, L.; Marttila, S.; Nevalainen, T.; Kummola, L.; Junttila, I.; Mononen, N.; Kähönen, M.; Raitakari, O. T.; Hervonen, A.; Jylhä, M.; Lehtimäki, T.; Hurme, M.; Jylhävä, J.
- Abstract
The epigenetic clock, defined as the DNA methylome age (DNAmAge), is a candidate biomarker of ageing. In this study, we aimed to characterize the behaviour of this marker during the human lifespan in more detail using two follow-up cohorts (the Young Finns study, calendar age i.e. cAge range at baseline 15–24 years, 25-year-follow-up, N = 183; The Vitality 90+ study, cAge range at baseline 19–90 years, 4-year-follow-up, N = 48). We also aimed to assess the relationship between DNAmAge estimate and the blood cell distributions, as both of these measures are known to change as a function of age. The subjects' DNAmAges were determined using Horvath's calculator of epigenetic cAge. The estimate of the DNA methylome age acceleration (Δ-cAge-DNAmAge) demonstrated remarkable stability in both cohorts: the individual rank orders of the DNAmAges remained largely unchanged during the follow-ups. The blood cell distributions also demonstrated significant intra-individual correlation between the baseline and follow-up time points. Interestingly, the immunosenescence-associated features (CD8+CD28− and CD4+CD28− cell proportions and the CD4/CD8 cell ratio) were tightly associated with the estimate of the DNA methylome age. In summary, our data demonstrate that the general level of Δ-cAge-DNAmAge is fixed before adulthood and appears to be quite stationary thereafter, even in the oldest-old ages. Moreover, the blood DNAmAge estimate seems to be tightly associated with ageing-associated shifts in blood cell composition, especially with those that are the hallmarks of immunosenescence. Overall, these observations contribute to the understanding of the longitudinal aspects of the DNAmAge estimate.
- Subjects
DNA methylation; BIOMARKERS; EPIGENETICS; FOLLOW-up studies (Medicine); IMMUNOSENESCENCE
- Publication
Age, 2016, Vol 38, Issue 3, p1
- ISSN
0161-9152
- Publication type
Article
- DOI
10.1007/s11357-016-9927-9