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- Title
Late recurrence of primitive neuroectodermal tumor/medulloblastoma.
- Authors
Lefkowitz Md, Ilene B.; Packer, Roger J.; Ryan, Stephen G.; Shah, Narin; Alavi, Jane; Rorke, Lucy B.; Sutton, Leslie N.; Schut, Luis; Lefkowitz, I B; Packer, R J; Ryan, S G; Shah, N; Alavi, J; Rorke, L B; Sutton, L N; Schut, L
- Abstract
The period of risk for recurrence of primitive neuroectodermal tumor/medulloblastoma (PNET/MB) is not clearly defined. With current treatment since more than 50% of children with PNET/MB can be expected to survive for at least 5 years after diagnosis, determining the evidence of "late" recurrence is of increasing concern. Collins has stated that patients with embryonal tumors who survive, disease free, for a period of time equal to the age at diagnosis plus 9 months can be declared cured. This, so-called Collins' law has been applied to patients with PNET/MB. To determine the incidence of "late" recurrence, factors which impact on recurrence and applicability of Collins' law, the authors studied all patients diagnosed with PNET/MB at the Children's Hospital of Philadelphia, Hospital of the University of Pennsylvania, Philadelphia, and Geisinger Medical Center, Danville, Pennsylvania, between 1970 and 1984. For the 44 patients in this study, the disease-free survival at 5, 10, and 12 years was 54%, 41% and 30%, respectively. For children surviving 5 years, the actuarial survival at 10 years was 75% and at 12 years, 51%. Age, sex, dose of radiotherapy, chemotherapy, or extent of surgery were not predictive of late relapse. Recurrence in three of seven patients (43%) occurred outside the "period of risk" as predicted by Collins. It appears that the "period of risk" for recurrent central nervous system tumors after PNET/MB is as yet undefined and probably indefinite.
- Publication
Cancer (0008543X), 1988, Vol 62, Issue 4, p826
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19880815)62:4<826::AID-CNCR2820620431>3.0.CO;2-M