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- Title
Nonneoplastic circulating Sézary-like cells in cutaneous T-cell lymphoma. Ultrastructural, immunologic, and T-cell receptor gene-rearrangement studies.
- Authors
Bendelac, Albert; Tj O'Connor, Nigel; Daniel, Marie-Thérèse; Boitard, Christian; Michel, Catherine; Laroche, Liliane; Lesavre, Philippe; Bach, Jean-François; Bendelac, A; O'Connor, N T; Daniel, M T; Boitard, C; Michel, C; Laroche, L; Lesavre, P; Bach, J F
- Abstract
Approximately 67% of peripheral blood lymphocytes in a case of nonmycosis fungoides-type cutaneous T-cell lymphoma, exhibited Sézary-like changes. Immunotyping showed a helper phenotype with an abnormally faint expression of the T3 membrane antigen, while quantitative electron microscopic study was suggestive of neoplasia. However, T-cell receptor gene study did not show any DNA rearrangement in Ficoll-separated blood lymphocytes, whereas clonal T-cell proliferation was simultaneously evidenced in cutaneous (non-Sézary-like) tumor cells. It is concluded that reactive nonneoplastic Sézary-like cells may be present not only in various benign conditions, as previously known, but also in T-cell lymphomas. This study provides further evidence for the nonspecificity of Sézary-like changes, and stresses the utility of T-cell receptor gene rearrangement study for diagnostic and prognostic procedures during the course of T-cell lymphoproliferative disorders.
- Publication
Cancer (0008543X), 1987, Vol 60, Issue 5, p980
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19870901)60:5<980::AID-CNCR2820600511>3.0.CO;2-9