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- Title
Malignant pheochromocytoma with ganglioneuroblastoma elements in a patient with von Recklinghausen's disease.
- Authors
Nakagawara, Akira; Ikeda, Keiichi; Tsuneyoshi, Masazumi; Daimaru, Yutaka; Enjoji, Munetomo; Nakagawara, A; Ikeda, K; Tsuneyoshi, M; Daimaru, Y; Enjoji, M
- Abstract
A 14-year-old girl with numerous café-au-lait spots in her skin was hospitalized because of fever, weight loss, and a mass of the right upper quadrant of the abdomen. Despite intensive chemotherapy, she died 6 months after admission. The autopsy revealed a right adrenal tumor with metastases to liver, lungs, vertebrae, and lymph nodes. Histologically the tumor was a pheochromocytoma with small foci of ganglioneuroblastoma. The catecholamine contents of the tumor were markedly elevated, as confirmed by the catecholamine fluorescence technique. Electron microscopically, the tumor cells contained intracytoplasmic membrane-bound chromaffin granules of varying sizes and shapes. This may be the first report of the concomitant occurrence of malignant catecholamine-secreting pheochromocytoma with ganglioneuroblastoma elements in a patient with von Recklinghausen's disease.
- Publication
Cancer (0008543X), 1985, Vol 55, Issue 12, p2794
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19850615)55:12<2794::AID-CNCR2820551213>3.0.CO;2-L