We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Dietary Fish-Oil Supplementation in Humans Reduces UVB-Erythemal Sensitivity but Increases Epidermal Lipid Peroxidation.
- Authors
Rhodes, Lesley E.; O'Farrell, Sheryl; Jackson, Malcolm J.; Friedmann, Peter S.
- Abstract
Ultraviolet radiation (UVR) - induced erythema may be mediated in part by free radical-generated tissue damage, including lipid peroxidation. We have examined the effect of dietary fish oil rich in ω-3 fatty acids upon susceptibility to UVB-induced erythema and epidermal lipid peroxidation. Fifteen volunteers took 10 g fish oil, containing 18% eicosapentaenoic acid and 12% docosahexaenoic acid, daily for 3 or 6 months. Sensitivity to UVB was assessed at intervals on fish oil, and 2.5 months after stopping treatment. Paired skin shave biopsies were taken from six subjects, at baseline and 3 months, from both irradiated and control skin. Fatty acid composition was analyzed and thiobarbituric acid-reactive substances measured as an index of lipid peroxidation. With increasing time on fish oil the minimal erythema dose rose progressively, from 18.9±13.9 mJ/cm² (mean±SD) at baseline to 41.1±16.6 mJ/cm² at 6 months, p < 0.01. Ten weeks after stopping fish oil the minimal erythema dose fell to 23.1±4.9 mJ/cm², p < 0.05. Epidermal total ω-3 fatty acids rose from 1.8±0.4% total fatty acids (mean±SEM) to 24.2±3.9% at 3 months, p <0.01. This was accompanied by a rise in thiobarbituric acid-reactive substances in irradiated skin from 6±0.3 (mean ± SEM) to 18.5±2.6 A532/g skin, p < 0.01. Hence dietary ω-3 fatty acids produce a pronounced reduction in UVB-erythemal sensitivity, although susceptibility of skin to lipid peroxidation is increased. Thus, ω-3 fatty acids may act as an oxidizable buffer, protecting more vital structures from free radical damage.
- Subjects
FISH oils; DIETARY supplements; ULTRAVIOLET radiation; ERYTHEMA; EPIDERMIS; PEROXIDATION
- Publication
Journal of Investigative Dermatology, 1994, Vol 103, Issue 2, p151
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12392604