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- Title
Radiation exposure and leukaemia risk among cohorts of persons exposed to low and moderate doses of external ionising radiation in childhood.
- Authors
Little, Mark P.; Wakeford, Richard; Zablotska, Lydia B.; Borrego, David; Griffin, Keith T.; Allodji, Rodrigue S.; de Vathaire, Florent; Lee, Choonsik; Brenner, Alina V.; Miller, Jeremy S.; Campbell, David; Pearce, Mark S.; Sadetzki, Siegal; Doody, Michele M.; Holmberg, Erik; Lundell, Marie; French, Benjamin; Adams, Michael Jacob; Berrington de González, Amy; Linet, Martha S.
- Abstract
Background: Many high-dose groups demonstrate increased leukaemia risks, with risk greatest following childhood exposure; risks at low/moderate doses are less clear. Methods: We conducted a pooled analysis of the major radiation-associated leukaemias (acute myeloid leukaemia (AML) with/without the inclusion of myelodysplastic syndrome (MDS), chronic myeloid leukaemia (CML), acute lymphoblastic leukaemia (ALL)) in ten childhood-exposed groups, including Japanese atomic bomb survivors, four therapeutically irradiated and five diagnostically exposed cohorts, a mixture of incidence and mortality data. Relative/absolute risk Poisson regression models were fitted. Results: Of 365 cases/deaths of leukaemias excluding chronic lymphocytic leukaemia, there were 272 AML/CML/ALL among 310,905 persons (7,641,362 person-years), with mean active bone marrow (ABM) dose of 0.11 Gy (range 0–5.95). We estimated significant (P < 0.005) linear excess relative risks/Gy (ERR/Gy) for: AML (n = 140) = 1.48 (95% CI 0.59–2.85), CML (n = 61) = 1.77 (95% CI 0.38–4.50), and ALL (n = 71) = 6.65 (95% CI 2.79–14.83). There is upward curvature in the dose response for ALL and AML over the full dose range, although at lower doses (<0.5 Gy) curvature for ALL is downwards. Discussion: We found increased ERR/Gy for all major types of radiation-associated leukaemia after childhood exposure to ABM doses that were predominantly (for 99%) <1 Gy, and consistent with our prior analysis focusing on <100 mGy.
- Publication
British Journal of Cancer, 2023, Vol 129, Issue 7, p1152
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/s41416-023-02387-8