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- Title
Vitamin D receptor gene polymorphisms and the risk of colorectal cancer in a Chinese population.
- Authors
Li, Cui; Li, Yi; Gao, Lin-Bo; Wang, Yan-Yun; Zhou, Bin; Lv, Mei-Li; Lu, Hui-Min; Zhang, Lin
- Abstract
<bold>Objective: </bold>The purpose was to investigate single nucleotide polymorphism of the vitamin D receptor gene and its possible relationship with colorectal cancer (CRC) in a Chinese population.<bold>Methods: </bold>The vitamin D receptor (VDR) genotypes were determined by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) using endonuclease BsmI and FokI, and direct sequencing in 400 Chinese people, comprised of 200 CRC patients and 200 controls from the same area in China.<bold>Results: </bold>The distribution of alleles (F/f) and genotypes (FF/Ff/ff) of the FokI had no significant difference between CRC patients and normal controls (P > 0.05), while that of the B allele and the BB genotype of the BsmI in CRC patients was significantly lower compared with the control group (0.1625 versus 0.740, P < 0.05, OR = 0.068, 95% CI: 0.048-0.096 and 0.060 versus 0.590, P < 0.05, OR = 0.015, 95% CI: 0.007-0.032).<bold>Conclusion: </bold>The BB genotype of the VDR BsmI variant was significantly associated with a decreased risk of CRC in a Chinese population, while the VDR FokI polymorphism was not significantly associated with it.
- Subjects
CHINA; ASIANS; CELL receptors; COLON tumors; COMPARATIVE studies; DISEASE susceptibility; GENETIC polymorphisms; RESEARCH methodology; MEDICAL cooperation; RECTUM tumors; RESEARCH; EVALUATION research; CASE-control method; GENOTYPES
- Publication
Digestive Diseases & Sciences, 2009, Vol 54, Issue 3, p634
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-008-0375-y