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- Title
Older males beget more mutations.
- Authors
Hurles, Matthew
- Abstract
Three papers characterizing human germline mutation rates bolster evidence for a relatively low rate of base substitution in modern humans and highlight a central role for paternal age in determining rates of mutation. These studies represent the advent of a transformation in our understanding of mutation rates and processes, which may ultimately have public health implications.
- Subjects
GENETIC mutation; GERM cells; PATERNAL age effect; CELL transformation; PUBLIC health; GERMPLASM
- Publication
Nature Genetics, 2012, Vol 44, Issue 11, p1174
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.2448