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- Title
Common variants of FUT2 are associated with plasma vitamin B<sub>12</sub> levels.
- Authors
Hazra, Aditi; Kraft, Peter; Selhub, Jacob; Giovannucci, Edward L.; Thomas, Gilles; Hoover, Robert N.; Chanock, Stephen J.; Hunter, David J.
- Abstract
We identified a strong association (P = 5.36 × 10−17) between rs492602 in FUT2 and plasma vitamin B12 levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602[G] allele had higher B12 levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B12 absorption and plasma levels.
- Subjects
HUMAN genetic variation; GENOMES; GENETIC code; NUCLEOTIDE sequence; BLOOD plasma
- Publication
Nature Genetics, 2008, Vol 40, Issue 10, p1160
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.210