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- Title
Role of the EGF +61A>G polymorphism in melanoma pathogenesis: an experience on a large series of Italian cases and controls.
- Authors
Casula M; Alaibac M; Pizzichetta MA; Bono R; Ascierto PA; Stanganelli I; Canzanella S; Palomba G; Zattra E; Palmieri G; Italian Melanoma Intergroup (IMI); Casula, Milena; Alaibac, Mauro; Pizzichetta, Maria A; Bono, Riccardo; Ascierto, Paolo A; Stanganelli, Ignazio; Canzanella, Sergio; Palomba, Grazia; Zattra, Edoardo
- Abstract
<bold>Background: </bold>A single nucleotide polymorphism (61A>G) in the epidermal growth factor (EGF) gene has been implicated in both melanoma pathogenesis and increased melanoma risk. To further evaluate this association, we conducted a case-control study in a clinic-based Italian population.<bold>Methods: </bold>Individuals with less than 10 (N = 127) or more than 100 (N = 128) benign nevi, and patients with cutaneous melanoma (N = 418) were investigated for the EGF +61A>G polymorphism, using an automated sequencing approach.<bold>Results: </bold>Overall, no difference in EGF genotype frequencies was observed among subjects with different number of nevi as well as when non-melanoma healthy controls were compared with the melanoma patients. However, a heterogeneous distribution of the frequencies of the G/G genotype was detected among cases and controls originating from North Italy (21.1 and 18.3%, respectively) vs. those from South Italy (12.6 and 17.1%, respectively).<bold>Conclusion: </bold>Our findings further suggest that EGF +61A>G polymorphism may have a limited impact on predisposition and/or pathogenesis of melanoma and its prevalence may vary in different populations.
- Publication
BMC Dermatology, 2009, Vol 9, p7
- ISSN
1471-5945
- Publication type
journal article
- DOI
10.1186/1471-5945-9-7