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- Title
Modified nucleic acids: replication, evolution, and next-generation therapeutics.
- Authors
Duffy, Karen; Arangundy-Franklin, Sebastian; Holliger, Philipp
- Abstract
Modified nucleic acids, also called xeno nucleic acids (XNAs), offer a variety of advantages for biotechnological applications and address some of the limitations of first-generation nucleic acid therapeutics. Indeed, several therapeutics based on modified nucleic acids have recently been approved and many more are under clinical evaluation. XNAs can provide increased biostability and furthermore are now increasingly amenable to in vitro evolution, accelerating lead discovery. Here, we review the most recent discoveries in this dynamic field with a focus on progress in the enzymatic replication and functional exploration of XNAs.
- Subjects
THERAPEUTICS
- Publication
BMC Biology, 2020, Vol 18, Issue 1, p1
- ISSN
1741-7007
- Publication type
Article
- DOI
10.1186/s12915-020-00803-6