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- Title
Overdose of dolutegravir in combination with tenofovir disaproxil fumarate/emtricitabine in suicide attempt in a 21-year old patient.
- Authors
Lee, Marcel; Eyer, Florian; Felgenhauer, Norbert; Klinker, Hartwig H. F.; Spinner, Christoph D.
- Abstract
A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose of his antiretroviral therapy (ART) comprising dolutegravir (DTG - Tivicay®) and tenofovir disaproxil fumarate/emtricitabine (Truvada®) in suicidal intention. On admission, the patient did not show any clinical signs of intoxication and laboratory findings were unremarkable. After 6 hours of intensive care monitoring, the patient was referred to a psychiatric clinic. 5 days after the day of intoxication, serum creatinine levels increased to high normal values (1.2 mg/dl). However, levels never exceeded the upper threshold. 8 and 12 weeks later, serum creatinine normalized to levels measured prior to the intoxication. No other adverse events occurred, and the patient does not suffer from permanent impairments.
- Subjects
BLOOD testing; COMBINATION drug therapy; HIV infections; MEDICAL referrals; SUBSTANCE abuse; SUICIDAL behavior; ANTIRETROVIRAL agents; PSYCHIATRIC treatment; TREATMENT effectiveness
- Publication
AIDS Research & Therapy, 2015, Vol 12, Issue 1, p1
- ISSN
1742-6405
- Publication type
Article
- DOI
10.1186/s12981-015-0054-y