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- Title
Amphetamine and mCPP Effects on Dopamine and Serotonin Striatal in vivo Microdialysates in an Animal Model of Hyperactivity.
- Authors
Nowak, Przemyslaw; Bortel, Aleksandra; Dabrowska, Joanna; Oswiecimska, Joanna; Drosik, Marzena; Kwiecinski, Adam; Opara, Jozef; Kostrzewa, Richard M.; Brus, Ryszard
- Abstract
In the neonatally 6-hydroxydopamine (6-OHDA)-lesioned rat hyperlocomotor activity, first described in the 1970s, was subsequently found to be increased by an additional lesion with 5,7-dihydroxytryptamine (5,7-DHT) (i.c.v.) in adulthood. The latter animal model (i.e., 134 µg 6-OHDA at 3 d postbirth plus 75 µg 5,7-DHT at 10 weeks; desipramine pretreatments) was used in this study, in an attempt to attribute hyperlocomotor attenuation by D,L-amphetamine sulfate (AMPH) and m-chlorophenylpiperazine di HCl (mCPP), to specific changes in extraneuronal (i.e., in vivo microdialysate) levels of dopamine (DA) and/or serotonin (5-HT). Despite the 98-99% reduction in striatal tissue content of DA, the baseline striatal microdialysate level of DA was reduced by 50% or less at 14 weeks, versus the intact control group. When challenged with AMPH (0.5 mg/kg), the microdialysate level of DA went either unchanged or was slightly reduced over the next 180 min (i.e., 20 min sampling), while in the vehicle group and 5,7-DHT (alone) lesioned group, the microdialysate level was maximally elevated by ∼225% and ∼450%, respectively -- and over a span of nearly 2 h. Acute challenge with mCPP (1 mg/kg salt form) had little effect on microdialysate levels of DA, DOPAC and 5-HT. Moreover, there was no consistent change in the microdialysate levels of DA, DOPAC, and 5-HT between intact, 5-HT-lesioned rats, and DA-lesioned rats which might reasonably account for an attenuation of hyperlocomotor activity. These findings indicate that there are other important neurochemical changes produced by AMPH-and mCPP-attenuated hyperlocomotor activity, or perhaps a different brain region or multiple brain regional effects are involved in AMPH and mCPP behavioral actions.
- Subjects
ANIMAL models in research; AMPHETAMINES; DOPAMINE; SEROTONIN; TISSUES
- Publication
Neurotoxicity Research, 2007, Vol 11, Issue 2, p131
- ISSN
1029-8428
- Publication type
Article
- DOI
10.1007/BF03033391