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- Title
Increase in Periodontal lnterleukin-1β Gene Expression Following Osseous Resective Surgery Using Conventional Rotary Instruments Compared with Piezosurgery: A Split-Mouth Randomized Clinical Trial.
- Authors
Aimetti, Mario; Ferrarotti, Francesco; Bergandi, Loredana; Saksing, Laura; Parducci, Francesca; Romano, Federica
- Abstract
The purpose of this study was to evaluate the early inflammatory response following osseous resective surgery (ORS) with Piezosurgery compared to commonly used diamond burs. A sample was selected of 24 bilateral posterior sextants requiring ORS in 12 chronic periodontitis patients in a split-mouth design. In 12 sextants, bone recontouring was performed using a piezoelectric device. In the contralateral sextants, rotary instruments were used. Sextants treated with Piezosurgery obtained similar 12-month clinical results but lower postsurgical gene expression of interleukin-1β (IL-1β), a well-known proinflammatory cytokine, and lower patient morbidity compared with sextants treated with rotary instruments. In spite of the longer surgical time, the use of Piezosurgery for ORS seems to promote more favorable wound healing compared with rotary instruments, as the lower pain and the low levels of IL-1β mRNA at the surgical sites suggest a milder underlying inflammatory response.
- Subjects
CHLORHEXIDINE; AMOXICILLIN; ANALYSIS of variance; BIOPSY; STATISTICAL correlation; GENE expression; INTERLEUKINS; LONGITUDINAL method; ORAL surgery; PERIODONTITIS; POLYMERASE chain reaction; POSTOPERATIVE care; PROBABILITY theory; STATISTICAL sampling; STATISTICS; T-test (Statistics); MATHEMATICAL variables; IBUPROFEN; DATA analysis; PAIN measurement; RANDOMIZED controlled trials; VISUAL analog scale; REPEATED measures design; REVERSE transcriptase polymerase chain reaction; DATA analysis software; DESCRIPTIVE statistics; MANN Whitney U Test; PIEZOSURGERY; ONE-way analysis of variance; FRIEDMAN test (Statistics); THERAPEUTICS
- Publication
International Journal of Periodontics & Restorative Dentistry, 2016, Vol 36, Issue 4, p489
- ISSN
0198-7569
- Publication type
Article
- DOI
10.11607/prd.2835