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- Title
Neuroendocrine Lung Tumors: Grade Correlates with Proliferation but not Angiogenesis.
- Authors
Arbiser, Zoya K.; Arbiser, Jack L.; Cohen, Cynthia; Gal, Anthony A.
- Abstract
In Thailand, the predominant HIV subtype is E, rather than Subtype B as in North America and Europe, and the predominant mode of transmission is heterosexual contact. Subtype E has the ability to replicate in vitro in Langerhans cells. We hypothesized that this cell type might constitute a reservoir for the HIV virus in vaginal mucosa of asymptomatic carriers. To examine this hypothesis, we compared vaginal tissue histology in HIV-1-seropositive cases with seronegative cases and determined the immunophenotype of HIV-1-infected cells, their numbers, and their distribution in vaginal mucosa. Vaginal biopsies were performed at four different sites from six asymptomatic HIV-1 Subtype E-infected persons and from six seronegative cases at necropsy and examined histologically. Immunophenotyping was performed using immunoperoxidase for Gag p24 HIV, CD3, CD20, CD68, CD1a, S-100 and p55 antigens and by double labeling, combining immunoperoxidase with alkaline phosphatase using pairs of the above antigens. Twenty of twenty-four vaginal biopsies (83.3%) from HIVseropositive cases showed definite inflammation compared to five of twenty-four vaginal necropsies (20.8%) from HIV-seronegative cases. One third of HIV-seropositive biopsies (8/24) demonstrated p24- positive cells in the epithelium, whereas threefourths (18/24) of the biopsies revealed p24-positive cells in the lamina propria. All seropositive patients showed positive cells in at least one biopsy, but not all biopsies contained positive cells. Infected cells were more frequently observed at sites of greater inflammation. The dendritic cell count in HIVseropositive vaginal epithelium was significantly higher than that observed in the seronegative cases (P = .004).
- Subjects
NEUROENDOCRINE tumors; LUNG cancer; NEOVASCULARIZATION; DENDRITIC cells; LANGERHANS cells; MUCOUS membranes; VAGINA abnormalities; CELL proliferation
- Publication
Modern Pathology, 2001, Vol 14, Issue 12, p1195
- ISSN
0893-3952
- Publication type
Article
- DOI
10.1038/modpathol.3880459