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- Title
Molecular Interrogation to Crack the Case of O‐GlcNAc.
- Authors
Estevez, Arielis; Zhu, Dongsheng; Blankenship, Connor; Jiang, Jiaoyang
- Abstract
The O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) modification, termed O‐GlcNAcylation, is an essential and dynamic post‐translational modification in cells. O‐GlcNAc transferase (OGT) installs this modification on serine and threonine residues, whereas O‐GlcNAcase (OGA) hydrolyzes it. O‐GlcNAc modifications are found on thousands of intracellular proteins involved in diverse biological processes. Dysregulation of O‐GlcNAcylation and O‐GlcNAc cycling enzymes has been detected in many diseases, including cancer, diabetes, cardiovascular and neurodegenerative diseases. Here, recent advances in the development of molecular tools to investigate OGT and OGA functions and substrate recognition are discussed. New chemical approaches to study O‐GlcNAc dynamics and its potential roles in the immune system are also highlighted. It is hoped that this minireview will encourage more research in these areas to advance the understanding of O‐GlcNAc in biology and diseases.
- Subjects
POST-translational modification; QUESTIONING; NEURODEGENERATION; CARDIOVASCULAR diseases; IMMUNE system
- Publication
Chemistry - A European Journal, 2020, Vol 26, Issue 53, p12086
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202000155