We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Expression Analysis of Carotid Plaques from Symptomatic and Asymptomatic Patients.
- Authors
Sintler, M.; Halligan, E.; Mahmood, A.; Butler, J.; Kitas, G. D.; Lunec, J.; Vohra, R.
- Abstract
Decision to perform a carotid endarterectomy is based on the risk of an affected vessel causing a serious clinical event offset against the risk of adverse surgical outcome. Not all plaques rupture. Understanding why they do could help treat those most at risk and avoid putting patients with stable plaques through hazardous procedures. Affymetrix GeneChips were used to quantify expression of 12,500 genes in carotid plaque tissue taken from 8 patients: 4 with clinical symptoms and 4 asymptomatic. The symptomatic expression profile was significantly different from non-symptomatic. 110 genes were at least 2 fold differentially expressed. In symptomatic patients, gene expression of collagen Type I, V, VI, X and XXI, fibronectin, chondroitin sulphate and TIMP-3 was decreased between 2 and 6 fold; MMP12, MMP 7, glutaredoxin and heme oxygenase-1 increased between 2 and 3.5 fold.
- Subjects
CAROTID artery; ENDARTERECTOMY; FIBRONECTINS; GLUTAREDOXIN; GENE expression; GENETIC regulation
- Publication
European Surgical Research, 2004, Vol 36, p15
- ISSN
0014-312X
- Publication type
Article