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- Title
High-salt d(CpGpCpG), a left-handed Z′ DNA double helix.
- Authors
Drew, Horace; Takano, Tsunehiro; Tanaka, Shoji; Itakura, Keiichi; Dickerson, Richard E.
- Abstract
The DNA tetramer d(CpGpCpG) or CGCG crystallizes from high-salt solution as a left-handed double helix, the Z′ helix. Its structure differs from that of the other known left-handed helix, Z-DNA, by a Cl′-exo sugar pucker at deoxyguanosines rather than C3′-endo, and these represent two alternative solutions to the same steric constraint arising from the syn glycosyl bond orientation. The apparent molecular basis for the Z to Z′ transition in going from intermediate to high salt is substitution of a bound anion for water at guanine amino groups, and consequent charge repulsion of anions and backbone phosphates.
- Publication
Nature, 1980, Vol 286, Issue 5773, p567
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/286567a0