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- Title
Gambogic acid inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the JNK, p38 and Akt signalling pathways.
- Authors
Jianjun Ma; Yan Ma; Xuqiang Liu; Shuai Chen; Chao Liu; An Qin; Shunwu Fan
- Abstract
Excessive osteoclast formation and bone resorption are key causes of osteoporosis. Natural compounds can serve as alternative therapeutic agents for the prevention and treatment of osteoporosis, and some natural compounds may have advantages over traditional drugs. In the present paper, we report that the natural compound GBA (gambogic acid), which is bioavailable, effective and less toxic, inhibits osteoclast formation, thereby attenuating osteoclastic bone resorption in vitro. Further in vivo studies demonstrated that GBA prevented ovariectomy-induced bone loss in a dose-dependent manner. Moreover, we demonstrated that GBA suppressed RANKL (receptor activator of nuclear factor B ligand)-induced JNK (c-Jun N-terminal kinase), p38 and Akt phosphorylation. Taken together, our results demonstrate that GBA inhibits osteoclast formation in vitro and in vivo, suggesting that it is of potential value in the treatment of osteoclast-related diseases.
- Subjects
DISEASE risk factors; OSTEOPOROSIS; OVARIECTOMY; OSTEOCLASTOGENESIS; SURGICAL complications; JNK mitogen-activated protein kinases
- Publication
Biochemical Journal, 2015, Vol 469, Issue 3, p399
- ISSN
0264-6021
- Publication type
Article
- DOI
10.1042/BJ20150151