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- Title
EP511 NEGATIVE PRESSURE WOUND THERAPY (NPWT) - AN ADDITIONAL EFFECTIVE THERAPEUTIC APPROACH IN THE TREATMENT OF ATYPICAL CHRONIC WOUNDS.
- Authors
Marijana Vicic; Cuzic, Domagoj; Kastelan, Marija; Brajac, Ines; Massari, Larisa Prpic
- Abstract
Aim: Multiple sclerosis (MS) is the commonest demyelinating disease of the central nervous system. Interferon beta (IFN β) is the most frequently prescribed drug to treat MS. A possible side effect of its administration is vasculitis, which leads to the formation of atypical chronic wounds notorious for slow healing. Negative pressure wound therapy (NPWT) is a treatment modality which uses negative pressure to help tissue healing. The use of NPWT has been recently significantly facilitated by the development of disposable and portable systems. Method: Case report. Results / Discussion: We present a 38-year-old woman with multiple necrotic ulcerations on her upper legs, upper arms and lower part of the abdomen. She was diagnosed with relapsing-remitting MS six months ago, after which she started subcutaneous selfinjections of IFN β. One month later, the redness, which gradually turned into necrosis, appeared at the drug application sites. Skin biopsy and direct immunofluorescence confirmed vasculitis. The patient was introduced to systemic corticosteroid, gel for autolytic debridement and polyurethane foam, but a partial wound improvement occurred. So, we decided on an additional NPWT/ Hydrofiber technology pump. Two months after the first examination, the condition of all wounds significantly improved, and all ulcers completely healed. Conclusion: MS is a chronic inflammatory disease that requires immunomodulatory therapy. The formation of cutaneous vasculitis and necrotic ulcerations after IFN β subcutaneous administration has been described. The treatment of vasculitis ulcers is complex. The atypical ulcerations that occurred in an MS patient after the IFN β application were successfully treated with systemic corticosteroids and NPWT application, which proved to be a practical, safe and effective treatment for hard-to-heal ulcers.
- Subjects
ITALY; WOUND healing; CHRONIC wounds &; injuries; CONFERENCES &; conventions; NEGATIVE-pressure wound therapy; TREATMENT effectiveness
- Publication
Journal of Wound Management, 2023, Vol 24, Issue 2, p324
- ISSN
2788-5771
- Publication type
Article