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- Title
© THE CATABOLISM OF ALLOANTIBODY IgG2a IN NORMAL AND HOMOGRAFT TOLERANT RATS.
- Authors
Fukumoto, T.; Kimura, H.; Miyamoto, M.; Brandon, M. R.
- Abstract
This article reports a study of the catabolism of alloantibody IgG2a in normal and homograft tolerant rats. In a normal immune response the disappearance of antibody from the circulation may be attributed to the formation of antigen-antibody complexes, a decrease in the synthetic rate and catabolism. in the present study, alloantibody activity was measured by its haemagglutination activity, as there is evidence in rats that it is possible to use red blood cells as a target to assess histocompatibility antigens. In every experiment, most of the tolerant rats had no significant amount of alloantibody in their serum prior to injection. However, this was supposed as a result of a low sensitivity of the alloantibody detection system.
- Subjects
METABOLISM testing; IMMUNOGLOBULIN G; IMMUNE complexes; ANTIGEN-antibody reactions; IMMUNE response; HOMOGRAFTS; TRANSPLANTATION immunology; LABORATORY mice
- Publication
Australian Journal of Experimental Biology & Medical Science, 1980, Vol 58, Issue 1, p41
- ISSN
0004-945X
- Publication type
Article
- DOI
10.1038/icb.1980.4