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- Title
Icariside II, a Naturally Occurring SIRT3 Agonist, Protects against Myocardial Infarction through the AMPK/PGC-1α/Apoptosis Signaling Pathway.
- Authors
Li, Yeli; Feng, Linying; Xie, Dianyou; Lin, Mu; Li, Yiqi; Chen, Nana; Yang, Danli; Gao, Jianmei; Zhu, Yizhun; Gong, Qihai
- Abstract
Effect of ICS II on SIRT3-KO Mice To further verify if loss of functional SIRT3 offsets ICS II preconditioning-induced cardioprotection in MI, WT and SIRT3-KO mice were treated with or without ICS II for 7 days prior to MI. ICS II Mitigated MI-Induced Myocardial Injury in Mice The left anterior descending coronary artery ligation-induced MI mice model was used to determine the effect of ICS II on MI-induced myocardial injury. Icariside II, a Naturally Occurring SIRT3 Agonist, Protects against Myocardial Infarction through the AMPK/PGC-1 /Apoptosis Signaling Pathway ICS II Inhibited Myocardial Apoptosis in Mice after MI We next investigated the role of apoptosis in the inhibitory effect of ICS II on MI.
- Subjects
CELLULAR signal transduction; SIRTUINS; MYOCARDIAL infarction; CELL anatomy; CORONARY artery bypass; REPERFUSION injury
- Publication
Antioxidants, 2022, Vol 11, Issue 8, pN.PAG
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox11081465