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- Title
局部使用辛伐他汀治疗牙周炎: 负荷对持续性的影响 药物释放系统或生物材料支架系统.
- Authors
刘小林; 柳树台; 汉字澳前; 木心月
- Abstract
BACKGROUND: Traditional periodontal therapy cannot restore periodontal soft and hard tissue. It is hoped to explore the effect of local simvastatin administration system on periodontitis, and open up a new way for clinical treatment of periodontitis. OBJECTIVE: To review the mechanisms of simvastatin on promoting periodontal bone regeneration and on treating periodontitis, as well as the advantages, disadvantages and preparation methods of local simvastatin drug delivery system, biomaterial scaffold system and local gel drug delivery system. MEDTHODS: The first author retrieved the articles published from 1988 to 2020 in PubMed, Wanfang, CNKI and other literature databases. The English key words were "simvastatin; microspheres; hydrogels; periodontitis; bone tissue engineering". The Chinese key words were "simvastatin; sustained drug release; biomaterial scaffold; gel system; periodontitis; bone tissue engineering". A total of 50 articles that met the criteria were included for review. RESULTS AND CONCLUSION: With the development of tissue engineering, experimental and clinical studies have mixed growth factors, scaffold materials and carriers to prepare copolymer with more biocompatibility, fluidity and promotion of bone regeneration, which is used to assist the treatment of periodontitis and has achieved good results. In recent years of research, some scholars loaded simvastatin on sustained release system; so me scholars loaded simvastatin on biomaterial stent system; some scholars loaded simvastatin on the gel drug delivery system. All these met hods have good slow-release drug effect, and promote the periodontal bone regeneration.
- Subjects
CONTROLLED release drugs; BONE regeneration; TISSUE engineering; BIOMATERIALS; SIMVASTATIN; GROWTH factors; TISSUE scaffolds; DRUG delivery systems
- Publication
Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu, 2022, Vol 26, Issue 16, p2720
- ISSN
2095-4344
- Publication type
Article
- DOI
10.12301/2022.263