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- Title
High pressure neurologic syndrome type 2 seizure in mice.
- Authors
McCall, R. D.; Frierson, D.
- Abstract
Progressive compression in helium/oxygen (heliox) atmospheres elicits in mice and many other vertebrates tested a complex series of effects known as the high pressure neurologic syndrome (HPNS). The most dramatic behavioral manifestations of the syndrome are two successive and distinct convulsive seizures, HPNS type 1 and type 2. In the present study, a maximum likelihood estimation procedure was applied to 11 models of inheritance of the difference in the time elapsed until manifestation of the type 2 seizure in heliox-compressed C57BL/6 and BALB/c mouse strains, their F hybrid, and the backcross generations. The “preferred” model specifying interaction between two major unlinked autosomal loci was confirmed indirectly by further breeding tests. The tests also showed that type 1 and type 2 seizure thresholds are uncorrelated but type 1 always preceded type 2. A challenge to the latter result involving mating backcross mice with high type 1 and type 2 seizure thresholds to mice with low type 1 and type 2 seizure thresholds produced no instance of alteration of the seizure order.
- Publication
Journal of Heredity, 1985, Vol 76, Issue 2, p89
- ISSN
0022-1503
- Publication type
Article
- DOI
10.1093/oxfordjournals.jhered.a110052