We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Brain imaging demonstrates a reduced neural impact of eating in obesity.
- Authors
Puzziferri, Nancy; Zigman, Jeffrey M.; Thomas, Binu P.; Mihalakos, Perry; Gallagher, Ryan; Lutter, Michael; Carmody, Thomas; Lu, Hanzhang; Tamminga, Carol A.
- Abstract
<bold>Objective: </bold>This study investigated functional brain response differences to food in women with BMI either <25 kg/m(2) (lean) or >35 kg/m(2) (severe obesity).<bold>Design and Methods: </bold>Thirty women, 18-65 years old, from academic medical centers participated. Baseline brain perfusion was measured with arterial spin labeling. Brain activity was measured via blood-oxygen-level-dependent functional magnetic resonance imaging in response to food cues, and appeal to cues was rated. Subjective hunger/fullness was reported pre- and post-imaging. After a standard meal, measures were repeated.<bold>Results: </bold>When fasting, brain perfusion did not differ significantly between groups; and both groups showed significantly increased activity in the neo- and limbic cortices and midbrain compared with baseline (P < 0.05, family-wise-error whole-brain corrected). Once fed, the lean group showed significantly decreased activation in these areas, especially the limbic cortex, whereas the group with severe obesity showed no such decreases (P < 0.05, family-wise-error whole-brain corrected). After eating, appeal ratings of food decreased only in lean women. Within groups, hunger decreased (P < 0.001) and fullness increased (P < 0.001) fasted to fed.<bold>Conclusions: </bold>While fasting, brain response to food cues in women did not differ significantly despite BMI. After eating, brain activity quickly diminished in lean women but remained elevated in women with severe obesity. These brain activation findings confirm previous studies.
- Subjects
BRAIN imaging; OBESITY in women; BODY weight; METABOLIC disorders; FASTING; FUNCTIONAL magnetic resonance imaging; PHYSIOLOGY; BRAIN physiology; COMPARATIVE studies; INGESTION; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; OBESITY; RESEARCH; RESEARCH funding; EVALUATION research
- Publication
Obesity (19307381), 2016, Vol 24, Issue 4, p829
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.21424