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- Title
Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways.
- Authors
Sekhar, Ashok; Rumfeldt, Jessica A. O.; Broom, Helen R.; Doyle, Colleen M.; Bouvignies, Guillaume; Meiering, Elizabeth M.; Kay, Lewis E.
- Abstract
The article presents a study that identifies the atomic-level characterization of superoxide dismutase (SOD1) to provide detailed understanding of the mechanisms in amyotrophic lateral sclerosis (ALS) pathology.
- Subjects
SUPEROXIDE dismutase; AMYOTROPHIC lateral sclerosis; NEUROMUSCULAR diseases
- Publication
eLife, 2015, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.07296