We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Antagonism of nicotinic acetycholinergic receptors by CN‐105, an apoE‐mimetic peptide reduces stroke‐induced excitotoxicity.
- Authors
Xue, Miaomiao; Li, Shuya; Xu, Mingzhi; Yan, Li; Laskowitz, Daniel T.; Kolls, Brad J.; Chen, Gang; Qian, Xiaohong; Wang, Yongjun; Song, Haifeng; Wang, Yi
- Abstract
An initial electrophysiological study using an HEK293 cell line overexpressing 7-nAChR showed that 10 M CN-105 strongly suppressed the ACh induced current, similar to the inhibitory effect of apoE (Figure S2). Dear Editor: This letter describes our work identifying the neuronal targets of a clinical-stage stroke therapeutics CN-105, and proposing a novel neuroprotective strategy involving nAChR antagonism. Antagonism of nicotinic acetycholinergic receptors by CN-105, an apoE-mimetic peptide reduces stroke-induced excitotoxicity Such effect was sub-type specific, as the IC SB 50 sb of CN-105 differed by two orders of magnitude for 7-, 4 2- and 1 1 -nAChR (Figure 1C), the latter of which might be responsible for CN-105's respiratory toxicity at supratherapeutic dosage.
- Subjects
PEPTIDES; NICOTINIC receptors; GLUTAMATE receptors; PRESYNAPTIC receptors; NICOTINIC acetylcholine receptors; BIOPHYSICS; NERVOUS system; CONTRACT research organizations
- Publication
Clinical & Translational Medicine, 2022, Vol 12, Issue 1, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.677