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- Title
Bariatric surgery decreases oxidative stress and protein glycosylation in patients with morbid obesity.
- Authors
Carmona‐Maurici, Júlia; Amigó, Núria; Cuello, Elena; Bermúdez, Marcelino; Baena‐Fustegueras, Juan Antonio; Peinado‐Onsurbe, Julia; Pardina, Eva
- Abstract
Background: There is growing evidence that oxidative stress (OS) is a critical factor linking obesity with its associated comorbidities, such as cardiovascular diseases. Aim: To evaluate the degree of OS in people with morbid obesity and its relationship with glycoproteins, determined using 1H‐NMR spectroscopy, before and after bariatric surgery (BS). Methods: In this observational cohort study, plasma from 24 patients with BMI ≥ 40 kg/m2 (age: 21‐65 years) was used to measure metabolites implicated in OS. We measured glycoprotein (GlycA, GlycB and GlycF) areas and shape factors (H/W = height/width). Results: One year after BS, oxidized low‐density lipoprotein had decreased by 49% (P <.0001), malondialdehyde by 32% (P =.0019) and lipoprotein (a) by 21% (P =.0039). The antioxidant enzymes paraoxonase‐1 and catalase increased after BS (43%, P <.0001 and 54%, P =.0002, respectively). Superoxide dismutase‐2 had fallen 1 year after BS (32%, P =.0052). After BS, both the glycoprotein areas and shape factors decreased by 20%‐26%. These glycoproteins were significantly correlated with OS parameters. The plasma atherogenic index was 63% higher in obese individuals than 1 year after BS and correlated positively with glycoproteins. Conclusion: For the first time, we here demonstrate the relationship between OS parameters and glycoproteins in people with morbid obesity. So glycoproteins could therefore be a good indicator, together with the oxidative state to assess patient prognosis after BS.
- Subjects
MORBID obesity; HEAT shock proteins; BARIATRIC surgery; OXIDATIVE stress; OVERWEIGHT persons; GASTRIC bypass; PROTON magnetic resonance spectroscopy
- Publication
European Journal of Clinical Investigation, 2020, Vol 50, Issue 11, p1
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/eci.13320