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- Title
Cryoballoon ablation of persistent atrial fibrillation for de novo pulmonary vein isolation: a single-center follow-up study.
- Authors
Zhong-Jing CAO; Xiao-Gang GUO; Qi SUN; Yan-Qiao CHEN; Hai-Yang XIE; Jian-Du YANG; Hui-Qiang WEI; Jia-Hui LI; Jian MA
- Abstract
BACKGROUND Pulmonary vein isolation (PVI) alone for persistent atrial fibrillation (PersAF) remains controversial. The characteristics of cryoballoon ablation (CBA) to treat PersAF and the blanking period recurrence are underreported. METHODS This study retrospectively analyzed patients with PersAF undergoing second-generation CBA for de novo PVI. The post-procedural efficacy and survival analysis were compared between patients with different PersAF durations. The multivariate Cox regression analysis was used to detect the risk factors for recurrence. Early and long-term recurrence were analyzed relative to each other. RESULTS A total of 329 patients were enrolled, with a median PersAF duration of 4.0 months (interquartile range: 2.0-12.0 months); 257 patients (78.1%) were male. Kaplan-Meier analysis of freedom from atrial fibrillation recurrence at 12, 24, and 30 months showed 71.0%, 58.5%, and 54.9%, respectively. Early PersAF had a relatively favorable survival rate and a narrow P-wave duration of restoring sinus rhythm compared with that of PersAF lasting more than three months (P < 0.05). The multivariate Cox regression analysis revealed that PersAF duration and left atrial anteroposterior diameter = 42 mm were the risk factors for atrial fibrillation recurrence after CBA [hazard ratio (HR) = 1.89, 95% CI: 1.01-1.4, P = 0.042; HR = 3.6, 95% CI: 2.4-5.4, P < 0.001, respectively]. The blanking period recurrence predicted the long-term recurrence (P < 0.0001). CONCLUSIONS CBA of PersAF had safety and efficacy to reach de novo PVI. The PersAF duration and left atrial size were risk factors for atrial fibrillation recurrence after CBA. Blanking period recurrence was associated with long-term recurrence.
- Subjects
DISEASE relapse; CONFIDENCE intervals; CHRONIC diseases; MULTIPLE regression analysis; CRYOSURGERY; CATHETER ablation; ATRIAL fibrillation; RETROSPECTIVE studies; TREATMENT effectiveness; RISK assessment; KAPLAN-Meier estimator; DESCRIPTIVE statistics; CATHETERIZATION; PULMONARY veins; LONGITUDINAL method; PROPORTIONAL hazards models; PATIENT safety; LEFT heart atrium; EVALUATION
- Publication
Journal of Geriatric Cardiology, 2022, Vol 19, Issue 10, p725
- ISSN
1671-5411
- Publication type
Article
- DOI
10.11909/j.issn.1671-5411.2022.10.001