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- Title
VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.
- Authors
Mangum, D S; Downie, J; Mason, C C; Jahromi, M S; Joshi, D; Rodic, V; Müschen, M; Meeker, N; Trede, N; Frazer, J K; Zhou, Y; Cheng, C; Jeha, S; Pui, C-H; Willman, C L; Harvey, R C; Hunger, S P; Yang, J J; Barnette, P; Mullighan, C G
- Abstract
The article presents a study which revealed that VPREB1 gene focal deletions are common in B-cell acute lymphoblastic leukemia (B-ALL) and occur independent of variable (joining) diversity (V(D)J) light chain recombination. It notes the correlation of focal deletions of VPREB1 with decreased expression levels and high-risk patients with focal deletions tend to have overall survival (OS). The central role of VPREB1 in B-cell development as part of the pre-B-cell receptor (pre-BCR) is tackled.
- Subjects
LYMPHOBLASTIC leukemia; DELETION mutation; GENE expression; B cells; CELL receptors
- Publication
Leukemia (08876924), 2014, Vol 28, Issue 1, p216
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/leu.2013.223