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- Title
The effect of royal jelly and silver nanoparticles on liver and kidney inflammation.
- Authors
Pourmobini, Hossein; Arababadi, Mohammad Kazemi; Salahshoor, Mohammad Reza; Roshankhah, Shiva; Taghavi, Mohammad Mohsen; Taghipour, Zahra; Shabanizadeh, Ahmad
- Abstract
Objective: Royal jelly (RJ) is a honey bee product for which, antiinflammatory properties were shown in vitro. Nanoparticles, including nano-silver (NS), are plausible inflammation inducers that act by activation of immune cells and consequent production of pro-inflammatory cytokines. This project aimed to explore immunomodulatory effects of royal jelly and nano-silver on the kidney and liver. Materials and Methods: In this project, 40 male rats were grouped as follows: 10 rats as controls, 10 rats treated with RJ; 10 rats treated with both NS and RJ and 10 rats treated with NS. Liver and kidney interleukin (IL)-1ß, -2, -6, and -33 levels were determined using commercial ELISA kits. Results: RJ reduced kidney IL-6 levels in comparison to control and NS--RJ groups. RJ and NS reduced kidney and liver IL-1ß levels. Kidney IL-33 levels were decreased in the RJ and nanosilver groups in comparison to the NS--RJ group. Conclusion: Based on this study, it may be concluded that RJ together with NS can play anti-inflammatory roles and may affect the function of immune cells.
- Subjects
ROYAL jelly; HEPATITIS; BEE products; HONEYBEES; SILVER nanoparticles; KIDNEYS
- Publication
Avicenna Journal of Phytomedicine, 2021, Vol 11, Issue 3, p218
- ISSN
2228-7930
- Publication type
Article