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- Title
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
- Authors
Takeuchi, Fumihiko; Akiyama, Masato; Matoba, Nana; Katsuya, Tomohiro; Nakatochi, Masahiro; Tabara, Yasuharu; Narita, Akira; Saw, Woei-Yuh; Moon, Sanghoon; Spracklen, Cassandra N.; Chai, Jin-Fang; Kim, Young-Jin; Zhang, Liang; Wang, Chaolong; Li, Huaixing; Li, Honglan; Wu, Jer-Yuarn; Dorajoo, Rajkumar; Nierenberg, Jovia L.; Wang, Ya Xing
- Abstract
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP. Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, the authors perform discovery GWAS for BP in East Asians and meta-analysis in East Asians and Europeans and report ancestry-specific BP SNPs and selection signals.
- Publication
Nature Communications, 2018, Vol 9, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-018-07345-0