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- Title
The relationship between atherosclerosis and total oxidant status in obese subjects.
- Authors
Asian, Mehmet; Sabuncu, Tevfik; Celik, Hakim; Erel, Ozcan
- Abstract
Obesity, the major health problems in westernized countries, is the important risk factors of atherosclerosis. It is associated with a significantly increased mortality from atherosclerotic cardiovascular disease and other causes. Furthermore, obesity is a risk factor of atherosclerosis, and are associated with increased oxidative stress. The objective of this study was to evaluate total oxidant status (TOS) in obese subjects and to establish the association between the development of atherosclerosis and TOS level in obese subjects. Twenty-seven obese subjects and 26 controls were enrolled in this study. To determine antioxidative status of serum, total antioxidant status.(TAS) was measured, and to determine the oxidant status of serum, TOS were measured. The ratio of TAC to TOS was accepted as oxidative stress index (OSI). Serum TAC levels was significantly lower in obese subjects than in controls (p< 0.001), while TOS levels and OSI values were significantly higher (p< 0.001, both of). There were significantly negative correlation between TAC and BMI (r:-0.552, p <0.001), while significantly positive correlations between TOS, OSI and BMI in obesity subjects (r: 0.745, p < 0.001, r: 0.707, p< 0.001). Our results indicate that obesity leads to oxidative stress which can contribute to pathogenesis of atherosclerosis. Furthermore, this novel method may be used as a routine test to evaluate and fallow up the levels of oxidative stress in obese subjects.
- Publication
Cell Membranes & Free Radical Research, 2008, Vol 1, Issue 1, p30
- ISSN
1308-416X
- Publication type
Article