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- Title
The Evolution of Thyroid Function after Presenting with Hashimoto Thyroiditis Is Different between Initially Euthyroid Girls with and Those without Turner Syndrome.
- Authors
Wasniewska, Malgorzata; Salerno, Mariacarolina; Corrias, andrea; Mazzanti, Laura; Matarazzo, Patrizia; Corica, Domenico; aversa, Tommaso; Messina, Maria Francesca; De Luca, Filippo; Valenzise, Mariella
- Abstract
Aim: To prospectively investigate, during a 5-year follow-up, whether the prognosis of thyroid function with Hashimoto thyroiditis (HT) is different in euthyroid girls with Turner syndrome (TS) than in euthyroid girls without TS. Design: In 66 TS girls and 132 non-TS girls with euthyroid HT and similar thyroid functional test results at HT diagnosis, we followed up the evolution of thyroid status over time. Results: At the end of follow-up, the TS girls exhibited higher TSH levels, lower fT 4 levels, and lower prevalence rates of both euthyroidism and subclinical hypothyroidism, but higher prevalence rates of both overt hypothyroidism and hyperthyroidism, irrespective of the karyotype. Conclusions: An association with TS is able to impair the long-term prognosis of thyroid function in girls with HT. Such an effect occurs irrespective of thyroid functional test results at HT diagnosis and is not necessarily linked with a specific karyotype.
- Subjects
THYROID gland physiology; THYROIDITIS; TURNER'S syndrome
- Publication
Hormone Research in Paediatrics, 2017, Vol 86, Issue 6, p403
- ISSN
1663-2818
- Publication type
Article
- DOI
10.1159/000452722