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- Title
Radiotherapy for metastatic fibrolamellar hepatocellular carcinoma.
- Authors
Peacock, Justin G.; Call, Jason A.; Olivier, Kenneth R.
- Abstract
Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare variant of hepatocellular carcinoma (HCC) that commonly affects young individuals without a prior history of liver disease. FLHCC commonly results in a better prognosis than HCC; however, the risk of recurrence and metastatic disease is high. FLHCC is typically treated by primary resection of the tumor with 50-75% cure rates. The use of radiation therapy in FLHCC has not been assessed on its own, and may show some success in a very few reported combination therapy cases. We report on the successful use of radiation therapy in a case of metastatic FLHCC to the lung following primary and secondary resections. Our treatment of the large, metastatic, pulmonary FLHCC tumor with 40 Gy in 10 fractions resulted in an 85.9% tumor volume decrease over six months. This suggests FLHCC may be a radiosensitive tumor and radiotherapy may be valuable in unresectable or metastatic tumors.
- Subjects
RADIOTHERAPY; LIVER cancer; ABDOMINAL pain; NAUSEA; ALPHA fetoproteins; COMPUTED tomography
- Publication
Rare Tumors, 2013, Vol 5, Issue 3, p101
- ISSN
2036-3605
- Publication type
Article
- DOI
10.4081/rt.2013.e28