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- Title
Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated.
- Authors
Ohkusa, Toshifumi; Fujiki, Kazuhiko; Takashimizu, Ichizen; Kumagai, Jiro; Tanizawa, Toru; Eishi, Yoshinobu; Yokoyama, Tetsuji; Watanabe, Mamoru; Ohkusa, T; Fujiki, K; Takashimizu, I; Kumagai, J; Tanizawa, T; Eishi, Y; Yokoyama, T; Watanabe, M
- Abstract
<bold>Background: </bold>Glandular atrophy and intestinal metaplasia are precancerous lesions; whether Helicobacter pylori eradication affects these lesions is controversial.<bold>Objective: </bold>To determine whether H. pylori eradication is associated with improvement in glandular atrophy and intestinal metaplasia after at least 1 year.<bold>Design: </bold>Single-blind, uncontrolled prospective trial.<bold>Setting: </bold>Academic gastroenterology clinic in Japan.<bold>Patients: </bold>163 consecutive patients with dyspepsia and H. pylori infection.<bold>Intervention: </bold>One-week course of a proton-pump inhibitor and antibiotic therapy.<bold>Measurements: </bold>Endoscopic examination with antral and corporal biopsy was done before treatment and at 1 to 3 and 12 to 15 months after treatment. Gastritis, atrophy, and metaplasia were graded according to the updated Sydney System.<bold>Results: </bold>In the 115 patients in whom H. pylori was eradicated, inflammation and mean neutrophil activity had decreased by 1 to 3 months, and both glandular atrophy in the corpus and intestinal metaplasia in the antrum had decreased by 12 to 15 months. Glandular atrophy in the corpus improved in 34 (89%) of 38 patients with atrophy before treatment, and intestinal metaplasia in the antrum improved in 28 (61%) of 46 patients who had metaplasia at baseline. In the 48 patients in whom eradication was unsuccessful, no significant histologic changes were observed.<bold>Conclusion: </bold>In the year after successful H. pylori eradication, precancerous lesions improved in most patients.
- Subjects
METAPLASIA; TREATMENT of helicobacter pylori infections; NEUTROPHILS
- Publication
Annals of Internal Medicine, 2001, Vol 134, Issue 5, p380
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-134-5-200103060-00010