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- Title
Effects of Radiotherapy for Nasopharyngeal Carcinoma on the Paranasal Sinuses: Study Based on...
- Authors
Chang, Cheng-Chuan; Chen, Mu-Kuan; Wen, Yung-Sung; Lee, Hong-Shen; Wu, Hwa-Koon; Liu, Mu-Tai
- Abstract
Objective: The purpose of this study was to determine if radiotherapy for nasopharyngeal carcinoma causes mucosal disease of the paranasal sinuses. Design: This study was a retrospective study. Setting: This study was conducted at a tertiary care centre. Method: A series of 69 newly diagnosed patients, without pre-existing sinus disease, who were treated with high-dose radiotherapy participated. Main Outcome Measures: The prevalence, severity, and time course of mucosal abnormalities were analyzed, as judged by consecutive computed tomographies (CTs). Results: The CT study revealed that 58.8% of the post-irradiation scans had mucosal disease of the sinuses. The maxillary sinus had the highest prevalence (42.3%) without statistical significance (p = .10). The difference by McNemar test for two follow-up scans was not significant (p = .48) and by Kappa test was significant (p = .04). The relationship between the prevalence and the time course post radiotherapy revealed that it remained a high prevalence until after the 4-year follow-up scans. Conclusions: The results of this study confirm that chronic sinus disease is a common late complication of radiotherapy and it persists for years. Thus, aggressive treatment is indicated.
- Subjects
RADIOTHERAPY; PARANASAL sinuses; NASOPHARYNX cancer; TOMOGRAPHY; CANCER
- Publication
Journal of Otolaryngology, 2000, Vol 29, Issue 1, p23
- ISSN
0381-6605
- Publication type
Article