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- Title
Dose-Dependent Inhibition of the Post-Prandial Glycaemic Response to a Standard Carbohydrate Meal following Incorporation of Alpha-Cyclodextrin.
- Authors
Buckley, Jonathan D.; Thorp, Alicia A.; Murphy, Karen J.; Howe, Peter R. C.
- Abstract
Background: This study evaluated the dose-response effects of α-cyclodextrin, a cyclic oligosaccharide, on the glycaemic and insulinaemic responses to the consumption of a standard carbohydrate meal. Methods: In a double-blind, randomised, cross-over design, 10 healthy subjects consumed boiled white rice containing 50 g of digestible carbohydrate to which 0 (control), 2, 5 or 10 g of α-cyclodextrin was added. Plasma glucose and insulin concentrations were determined prior to and for 2 h after consumption of each meal. Results: The area under the plasma glucose curve was negatively related to the dose of α-cyclodextrin (r2 = 0.97, p = 0.02), with the areas being significantly reduced at the 5- and 10-gram doses compared with the control (p < 0.05). α-Cyclodextrin did not affect the area under the plasma insulin curve (p = 0.39). Higher doses of α-cyclodextrin resulted in greater satiety, but were associated with reduced palatability and an increased incidence of minor gastrointestinal complaints (stomach ache, nausea, bloating). Conclusion: α-Cyclodextrin reduces the glycaemic response to a standard carbohydrate meal in a dose-dependent manner and may be useful as an ingredient for reducing the glycaemic impact of such foods. Copyright © 2006 S. Karger AG, Basel
- Subjects
CARBOHYDRATES; CYCLODEXTRINS; INSULIN; RICE; BLOOD sugar
- Publication
Annals of Nutrition & Metabolism, 2006, Vol 50, Issue 2, p108
- ISSN
0250-6807
- Publication type
Article
- DOI
10.1159/000090498