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- Title
Associations Between G/A<sup>1229</sup>, A/G<sup>3944</sup>, T/C<sup>30875</sup>, C/T<sup>48200</sup> and C/T<sup>65013</sup> Genotypes and Haplotypes in the Vitamin D Receptor Gene, Ultraviolet Radiation and Susceptibility to Prostate Cancer.
- Authors
Moon, Sam; Holley, Sarah; Bodiwala, Dhaval; Luscombe, Christopher J.; French, Michael E.; Liu, Samson; Saxby, Mark F.; Jones, Peter W.; Fryer, Anthony A.; Strange, Richard C.
- Abstract
Ultraviolet radiation (UVR) may protect against prostate cancer via a mechanism involving vitamin D. Thus, the vitamin D receptor ( VDR) gene is a susceptibility candidate, though published data are discrepant. We studied the association of prostate cancer risk with five VDR single nucleotide polymorphisms (SNPs): G/A1229 (SNP 1), A/G3944 (SNP 2), T/C30875 (SNP 3), C/T48200 (SNP 4) and C/T65013 (SNP 5), in 430 cancer and 310 benign prostatic hypertrophy (BPH) patients. The SNP 2 GG genotype frequency was lower in cancer than BPH patients (odds ratio = 0.63, 95% CI = 0.41–0.98, p = 0.039). SNPs 1 and 2, and SNPs 4 and 5, were in linkage disequilibrium. Two copies of haplotypes comprising SNPs 1-2, G-G (odds ratio = 0.63, p = 0.039), SNPs 2-3 G-C (odds ratio = 0.45, p = 0.008) and SNPs 1-2-3 G-G-C (odds ratio = 0.44, p = 0.006), but not SNPs 1-3, G-C (odds ratio = 0.81, p = 0.34), were associated with reduced risk (reference, no copies of the haplotypes). These associations were observed after stratification of subjects by extent of UVR exposure. These data show that SNP 2 GG genotype mediates prostate cancer risk, complementing studies reporting this allele is protective in malignant melanoma pathogenesis. They further suggest that published associations of risk with SNP 1 may result from linkage disequilibrium with SNP 2.
- Subjects
PROSTATE diseases; VITAMIN D; ULTRAVIOLET radiation; RECEPTOR antibodies; CANCER patients; GENETIC polymorphisms
- Publication
Annals of Human Genetics, 2006, Vol 70, Issue 2, p226
- ISSN
0003-4800
- Publication type
Article
- DOI
10.1111/j.1529-8817.2005.00219.x