We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Cyclic Marinopyrrole Derivatives as Disruptors of Mcl-1 and Bcl-x<sub>L</sub> Binding to Bim.
- Authors
Chunwei Cheng; Yan Liu; Balasis, Maria E.; Simmons, Nicholas L.; Jerry Li; Hao Song; Lili Pan; Yong Qin; Nicolaou, K. C.; Sebti, Said M.; Rongshi Li
- Abstract
A series of novel cyclic marinopyrroles were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Both atropisomers of marinopyrrole A (1) show similar potency. A tetrabromo congener 9 is two-fold more potent than 1. Two novel cyclic marinopyrroles (3 and 4) are two- to seven-fold more potent than 1.
- Subjects
PROTEINS; PROSPECTING; ATROPISOMERS; CARBON tetrabromide; ENZYME-linked immunosorbent assay
- Publication
Marine Drugs, 2014, Vol 12, Issue 3, p1335
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md12031335