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- Title
Inhibition of Transforming Growth Factor-ß Production in Brain Pericytes Contributes to Cyclosporin A-Induced Dysfunction of the Blood-Brain Barrier.
- Authors
Fuyuko Takata; Shinya Dohgu; Atsushi Yamauchi; Noriko Sumi; Shinsuke Nakagawa; Mikihiko Naito; Takashi Tsuruo; Hideki Shuto; Yasufumi Kataoka
- Abstract
1. The present study was designed to clarify whether brain pericytes and pericyte-derived transforming growth factor-β1 (TGF-β1) participate in cyclosporin A (CsA)-induced dysfunction of the blood-brain barrier (BBB). 2. The presence of brain pericytes markedly aggravated CsA-increased permeability of MBEC4 cells to sodium fluorescein and accumulation of rhodamine 123 in MBEC4 cells. 3. Exposure to CsA significantly decreased the levels of TGF-β1 mRNA in brain pericytes in pericyte co-cultures. Treatment with TGF-β1 dose-dependently inhibited CsA-induced hyperpermeability and P-glycoprotein dysfunction of MBEC4 cells in pericyte co-cultures. 4. These findings suggest that an inhibition of brain pericyte-derived TGF-β1 contributes to the occurrence of CsA-induced dysfunction of the BBB.
- Publication
Cellular & Molecular Neurobiology, 2007, Vol 27, Issue 3, p317
- ISSN
0272-4340
- Publication type
Article
- DOI
10.1007/s10571-006-9125-x