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- Title
A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
- Authors
Brouwer, Remco de; Rijdt, Wouter P te; Hoorntje, Edgar T; Amin, Ahmad; Asselbergs, Folkert W; Cox, Moniek G P J; Heijden, Jeroen F van der; Hillege, Hans; Karper, Jacco C; Mahmoud, Belend; van der Meer, Peter; Oomen, Anton; Riele, Anneline S J M te; Silljé, Herman H W; Tan, Hanno L; Tintelen, Jan Peter van; Veldhuisen, Dirk J van; Westenbrink, Berend Daan; Wiesfeld, Ans C P; Willems, Tineke P
- Abstract
Keywords: Phospholamban; Eplerenone; Fibrosis; Cardiomyopathy; Heart failure; Randomized clinical trial EN Phospholamban Eplerenone Fibrosis Cardiomyopathy Heart failure Randomized clinical trial 4284 4287 4 10/25/23 20231021 NES 231021 Introduction Phospholamban ( I PLN i ; p.Arg14del) cardiomyopathy is an inherited disease caused by the pathogenic p.Arg14del variant in the I PLN i gene. The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unresponsive to standard heart failure therapy. Future research into I PLN i p.Arg14del cardiomyopathy disease progression or modification - and more broadly, research into asymptomatic carriers of pathogenic variations associated with genetic cardiomyopathies - may be better designed using the knowledge obtained in this study. Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy.
- Subjects
PHOSPHOLAMBAN; ARRHYTHMIA; RANDOMIZED controlled trials; ARRHYTHMOGENIC right ventricular dysplasia; VENTRICULAR arrhythmia; HEART failure; CARDIAC magnetic resonance imaging
- Publication
European Heart Journal, 2023, Vol 44, Issue 40, p4284
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/ehad292