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- Title
Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome.
- Authors
Sander, Katrin N.; Kim, Dong-Hyun; Ortori, Catharine A.; Warren, Averil Y.; Anyanwagu, Uchenna C.; Hay, Daniel P.; Broughton Pipkin, Fiona; Khan, Raheela N.; Barrett, David A.
- Abstract
Introduction: Pre-eclampsia is a hypertensive gestational disorder that affects approximately 5% of all pregnancies. Objectives: As the pathophysiological processes of pre-eclampsia are still uncertain, the present case–control study explored underlying metabolic processes characterising this disease. Methods: Maternal peripheral plasma samples were collected from pre-eclamptic (n = 32) and healthy pregnant women (n = 35) in the third trimester. After extraction, high-resolution mass spectrometry-based untargeted metabolomics was used to profile polar and apolar metabolites and the resulting data were analysed via uni- and multivariate statistical approaches. Results: The study demonstrated that the metabolome undergoes substantial changes in pre-eclamptic women. Amongst the most discriminative metabolites were hydroxyhexacosanoic acid, diacylglycerols, glycerophosphoinositols, nicotinamide adenine dinucleotide metabolites, bile acids and products of amino acid metabolism. Conclusions: The putatively identified compounds provide sources for novel hypotheses to help understanding of the underlying biochemical pathology of pre-eclampsia.
- Subjects
AMINO acid metabolism; METABOLITES; PREGNANT women; BILE acids; PREECLAMPSIA; METABOLIC profile tests
- Publication
Metabolomics, 2019, Vol 15, Issue 12, p1
- ISSN
1573-3882
- Publication type
Article
- DOI
10.1007/s11306-019-1600-8