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- Title
Targeting the Hippo signalling pathway for cancer treatment.
- Authors
Keisuke Nakatani; Tomohiko Maehama; Miki Nishio; Hiroki Goto; Wakako Kato; Hirofumi Omori; Yosuke Miyachi; Hideru Togashi; Yohei Shimono; Akira Suzuki
- Abstract
The Hippo signalling pathway monitors cell-cell contact and external factors that shape tissue structure. In mice, tumourigenesis and developmental abnormalities are common consequences of dysregulated Hippo signalling. Expression of Hippo pathway components is also frequently altered in human tumours and correlates with poor prognosis and reduced patient survival. Thus, the Hippo pathway is an attractive anti-cancer target. Here, we provide an overview of the function and regulation of Hippo signalling components and summarize progress to date on the development of agents able to regulate Hippo signalling for cancer therapy.
- Subjects
CANCER treatment; CELLULAR signal transduction; CELL proliferation; TISSUES; CELL communication; KINASE regulation; LABORATORY mice; ANATOMY
- Publication
Journal of Biochemistry, 2017, Vol 161, Issue 3, p237
- ISSN
0021-924X
- Publication type
Article
- DOI
10.1093/jb/mvw074