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- Title
Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches.
- Authors
Orth, Michael; Metzger, Philipp; Gerum, Sabine; Mayerle, Julia; Schneider, Günter; Belka, Claus; Schnurr, Maximilian; Lauber, Kirsten
- Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine therapeutic failure. In this review, we present the current status and the recent advances in PDAC treatment together with the biological and immunological hallmarks of this cancer entity. On this basis, we discuss new concepts combining distinct treatment modalities in order to improve therapeutic efficacy and clinical outcome - with a specific focus on protocols involving radio(chemo)therapeutic approaches.
- Subjects
COMBINED modality therapy
- Publication
Radiation Oncology, 2019, Vol 14, Issue 1, pN.PAG
- ISSN
1748-717X
- Publication type
journal article
- DOI
10.1186/s13014-019-1345-6