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- Title
Advances in research on virulence factors of Acinetobacter baumannii and their potential as novel therapeutic targets.
- Authors
Zhou, Jian-Xia; Feng, Ding-Yun; Li, Xia; Zhu, Jia-Xin; Wu, Wen-Bin; Zhang, Tian-tuo
- Abstract
Acinetobacter baumannii is a strictly aerobic, nonmotile, nonfermenting, gram-negative bacillus. It is a highly infectious and invasive pathogen with high mortality and morbidity rates among immunodeficient patients. Due to increasing levels of drug resistance and the inefficiency of existing antimicrobial treatments, it is crucial to develop novel agents to control this pathogen. Several recent studies have investigated virulence factors that are associated with the pathogenesis of A. baumannii , and could thus serve as novel therapeutic targets. The present review comprehensively summarizes the current understanding of these virulence factors and their mechanisms in A. baumannii. We also highlight factors that could be potential therapeutic targets, as well as list candidate virulence factors for future researchers and clinical practitioners.
- Subjects
DRUG target; ACINETOBACTER baumannii; GRAM-negative bacteria; DRUG resistance; DEATH rate
- Publication
Journal of Applied Microbiology, 2023, Vol 134, Issue 2, p1
- ISSN
1364-5072
- Publication type
Article
- DOI
10.1093/jambio/lxac089