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- Title
The Binding of Murine IgM to Staphylococcal A Protein.
- Authors
MacKenzie, M. R.; Gutman, G. A.; Warner, N. L.
- Abstract
The binding or Staph A protein to murine immunoglobulins has previously been thought to be restricted to the IgG2 and IgG3 classes. In this study five IgM proteins were assessed for binding, and of these one showed marked Staph A binding. Pepsin digestion of this IgM molecule produced several different sized fragments, and the binding studies with these fragments indicated that the binding site is in the CH2 domain.
- Subjects
IMMUNOGLOBULIN M; MACROGLOBULINS; STAPHYLOCOCCAL protein A; BACTERIAL cell walls; STAPHYLOCOCCUS aureus; BACTERIAL immunoglobulin-binding proteins; PEPSIN; IMMUNOLOGY
- Publication
Scandinavian Journal of Immunology, 1978, Vol 7, Issue 5, p367
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1978.tb00466.x